micro-matrix

the next generation in microbioreactors

The unique micro-Matrix offers total control over 24 independent bioreactors in a simple microtiter plate footprint.
Each of the 24 bioreactors on a plate offer independent controls like its larger stirred-tank relatives:

pH (measurement and two-sided control)
temperature (measurement and two-sided control, including plate-wide gradients)
dissolved oxygen control (measurement and two-sided control)
individual liquid additions (including feeding profiles)
up to 4 separate gas additions (individually controlled)

The micro-Matrix is a true scale down of small scale bioreactors. The bioreactor square well cassette design is based upon our popular SBS-format microtiter plates that maximize mixing, optimize gas transfer, and seamlessly integrate into lab automation protocols. The PC-based human interface of the micro-Matrix reflects our popular my-Control interface and offers simple, intuitive interaction with each of the 24 bioreactors.

Integrated LEDs indicate the status of the bioreactors (inactive / active / alarm) with color-based feedback so that operators can get instant process information with one quick glance. 

Each bioreactor has its own PID controller for pH, dissolved oxygen, and temperature. Individual pH control can be achieved via gas addition, liquid addition, or a combination of both. Dissolved oxygen level can be individually controlled by up to four gas additions per bioreactor.

Temperature can be individually controlled by the integrated cooling and heating system on a well-by-well basis, and users can define temperature gradients across the set of bioreactors.  Each well has its individual Peltier element for cooling and heating and the complete system can be equipped with the optional cooling system to lower the temperature of the cultivation chamber.

Advanced control strategies are also available to users interested in cascade controls (up to 5 actuators per process variable), time-based setpoint changes, and event-triggered liquid feeds. Liquid feeding is also available using varying types of addition profiles.